Erratum for Gui et al., Electron Tomography Imaging of Surface Glycoproteins on Human Parainfluenza Virus 3: Association of Receptor Binding and Fusion Proteins before Receptor Engagement
نویسندگان
چکیده
Long Gui,a,b Eric Jurgens,c Jamie L. Ebner,a Matteo Porotto,c Anne Moscona,c,d Kelly K. Leea,b,e Department of Medicinal Chemistry, University of Washington, Seattle, Washington, USAa; Biological Physics Structure and Design Graduate Program, University of Washington, Seattle, Washington, USAb; Department of Pediatrics, Weill Medical College of Cornell University, New York, New York, USAc; Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, USAd; Department of Microbiology, University of Washington, Seattle, Washington, USAe
منابع مشابه
Electron Tomography Imaging of Surface Glycoproteins on Human Parainfluenza Virus 3: Association of Receptor Binding and Fusion Proteins before Receptor Engagement
UNLABELLED In order to deliver their genetic material to host cells during infection, enveloped viruses use specialized proteins on their surfaces that bind cellular receptors and induce fusion of the viral and host membranes. In paramyxoviruses, a diverse family of single-stranded RNA (ssRNA) viruses, including several important respiratory pathogens, such as parainfluenza viruses, the attachm...
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Human parainfluenza viruses cause several serious respiratory diseases in children for which there is no effective prevention or therapy. Parainfluenza viruses initiate infection by binding to cell surface receptors and then, via coordinated action of the 2 viral surface glycoproteins, fuse directly with the cell membrane to release the viral replication machinery into the host cell's cytoplasm...
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Paramyxoviruses, including the childhood respiratory pathogen human parainfluenza virus type 3 (HPIV3), possess an envelope protein hemagglutinin-neuraminidase (HN) that has receptor-cleaving (neuraminidase), as well as receptor-binding, activity. HN is a type II transmembrane glycoprotein, present on the surface of the virus as a tetramer composed of two dimers. HN is also essential for activa...
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The human parainfluenza virus type 3 (HPIV3) fusion (F) and hemagglutinin-neuraminidase (HN) glycoproteins are the principal components involved in virion receptor binding, membrane penetration, and ultimately, syncytium formation. While the requirement for both F and HN in this process has been determined from recombinant expression studies, stable physical association of these proteins in coi...
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عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2016